Dimethindene( Dimetindene | Dimetindeno )

Catalog No. M27978 CAS No. 5636-83-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Dimethindene
Note

Research use only, not for human use.
Brief Description

Dimethylbutyl is an antihistamine/anticholinergic drug. It is administered orally and used to relieve itching locally.
Description

Dimethylbutyl is an antihistamine/anticholinergic drug. It is administered orally and used to relieve itching locally.(In Vitro):In follicle-enclosed Xenopus oocytes, Dimethindene (5-500 μM) decreases Cromakalim cromakalim-induced K+ currents (IC50 = 29.5 μM).(In Vivo):In C57BL/6 mice with skin wound healing, Dimethindene (0.25 mg; i.p.) impairs cutaneous wound healing and delays skin wound closure.
In Vitro

Dimethindene (5-500 μM; follicle-enclosed Xenopus oocytes) decreases Cromakalim cromakalim-induced K+ currents with an IC50 value of 29.5 μM.
In Vivo

Dimethindene (0.25 mg; i.p.; once; C57BL/6 mice with skin WH) impaires cutaneous wound healing (WH) and delays skin wound closure. Animal Model:C57BL/6 mice with skin WH Dosage:0.25 mg Administration: intraperitoneal injection; once Result:Delayed skin wound closure as compared to vehicle treated mice.
Synonyms

Dimetindene | Dimetindeno
Pathway

Others
Target

Other Targets
Recptor

Hedgehog|Apoptosis
Research Area

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Indication

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1.Officioso A, et al. Triggering of Erythrocyte Death by Triparanol. Toxins (Basel). 2015 Aug 24;7(8):3359-71.

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