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Dimethindene

CAS No. 5636-83-9

Dimethindene( Dimetindene | Dimetindeno )

Catalog No. M27978 CAS No. 5636-83-9

Dimethylbutyl is an antihistamine/anticholinergic drug. It is administered orally and used to relieve itching locally.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Dimethindene
  • Note
    Research use only, not for human use.
  • Brief Description
    Dimethylbutyl is an antihistamine/anticholinergic drug. It is administered orally and used to relieve itching locally.
  • Description
    Dimethylbutyl is an antihistamine/anticholinergic drug. It is administered orally and used to relieve itching locally.(In Vitro):In follicle-enclosed Xenopus oocytes, Dimethindene (5-500 μM) decreases Cromakalim cromakalim-induced K+ currents (IC50 = 29.5 μM).(In Vivo):In C57BL/6 mice with skin wound healing, Dimethindene (0.25 mg; i.p.) impairs cutaneous wound healing and delays skin wound closure.
  • In Vitro
    Dimethindene (5-500 μM; follicle-enclosed Xenopus oocytes) decreases Cromakalim cromakalim-induced K+ currents with an IC50 value of 29.5 μM.
  • In Vivo
    Dimethindene (0.25 mg; i.p.; once; C57BL/6 mice with skin WH) impaires cutaneous wound healing (WH) and delays skin wound closure. Animal Model:C57BL/6 mice with skin WH Dosage:0.25 mg Administration: intraperitoneal injection; once Result:Delayed skin wound closure as compared to vehicle treated mice.
  • Synonyms
    Dimetindene | Dimetindeno
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Hedgehog|Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    5636-83-9
  • Formula Weight
    292.426
  • Molecular Formula
    C20H24N2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C1=C(CCN(C)C)Cc2ccccc12)c1ccccn1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Officioso A, et al. Triggering of Erythrocyte Death by Triparanol. Toxins (Basel). 2015 Aug 24;7(8):3359-71.
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