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Home - Products - Others - Other Targets - 2-Hydroxy-1,7,8-trimethoxy-3-methyl-9,10-anthracenedione

2-Hydroxy-1,7,8-trimethoxy-3-methyl-9,10-anthracenedione

CAS No. 2195434-05-8

2-Hydroxy-1,7,8-trimethoxy-3-methyl-9,10-anthracenedione( ——— )

Catalog No. M38228 CAS No. 2195434-05-8

OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    2-Hydroxy-1,7,8-trimethoxy-3-methyl-9,10-anthracenedione
  • Note
    Research use only, not for human use.
  • Brief Description
    OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage.
  • Description
    OAT1/3-IN-2 (compound 8) is a dual inhibitor of OAT1 and OAT3. OAT1/3-IN-2 can reverse the toxicity of Cys-Hg on HEK-OAT1 cells (10 μM) and has a potential protective effect on the kidneys. OAT1/3-IN-2 can be used to study mercury-induced kidney damage.
  • In Vitro
    ———
  • In Vivo
    ———
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Organic anion transporter 1 and 3 (OAT1 and OAT3)
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    2195434-05-8
  • Formula Weight
    328.32
  • Molecular Formula
    C18H16O6
  • Purity
    >98% (HPLC)
  • Solubility
    ———
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang X, et al. From the Cover: Identification of Natural Products as Inhibitors of Human Organic Anion Transporters (OAT1 and OAT3) and Their Protective Effect on Mercury-Induced Toxicity. Toxicol Sci. 2018 Feb 1;161(2):321-334.?2.
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