alpha-Naphthoflavone

Research use only, not for human use.

Alpha-Naphthoflavone, a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.

Alpha-Naphthoflavone, a synthetic flavonoid, is a potent inhibitor of aromatase with an I50 value of 0.5 μM.

Cell Proliferation Assay Cell Line:HeLa Concentration:0.01, 1, 10, 100 μM Incubation Time:6 days Result:Decreased cell proliferation in a dose-dependent manner with IC50 value of 36.81 μM.Apoptosis Analysis Cell Line:HeLa Concentration:50 μM Incubation Time:12, 24, 36 h Result:Induced a mild but significant apoptosis rate.Western Blot Analysis Cell Line:HeLa Concentration:50 μM Incubation Time:12, 24, 36 h Result:Increased the level of p53 at 12 h.

Animal Model:HFD-induced mice model Dosage:80, 160 mg/kg Administration:i.g.Result:Decreased the levels of AST, TG and TC.

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Others

Other Targets

Aromatase

Others-Field

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604-59-1

272.3

C19H12O2

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (91.81 mM)

C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3

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(-20℃)

With Ice Pack

≥ 2 years