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BMT-124110
CAS No. 1679371-59-5
BMT-124110( —— )
Catalog No. M32813 CAS No. 1679371-59-5
BMT-124110 is a selective AAK1 inhibitor (IC50: 0.9 nM) with antinociceptive activity. BMT-090605 inhibited BMP-2 induced protein kinase BIKE with IC50 of 17 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 500 | Get Quote |
|
| 5MG | 758 | Get Quote |
|
| 10MG | 1036 | Get Quote |
|
| 25MG | 1518 | Get Quote |
|
| 50MG | 2052 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBMT-124110
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NoteResearch use only, not for human use.
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Brief DescriptionBMT-124110 is a selective AAK1 inhibitor (IC50: 0.9 nM) with antinociceptive activity. BMT-090605 inhibited BMP-2 induced protein kinase BIKE with IC50 of 17 nM.
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DescriptionBMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively.
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In VitroBMT-124110 shows a cellular IC50 of 3.2±1.4 nM for AAK1.
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In VivoBMT-124110 is added directly onto the spinal corevd by microiontophoresis, leading to reduction in windup-induced activity in 10 of 14 animals.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorAAK1 (AP2 associated kinase 1)
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Research Area——
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Indication——
Chemical Information
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CAS Number1679371-59-5
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Formula Weight369.46
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Molecular FormulaC21H27N3O3
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Purity>98% (HPLC)
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Solubility——
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SMILESN(C(C)=O)C=1C=C2C=3C(=CC(OC[C@@](CC(C)C)(C)N)=CC3)OCC2=CN1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.?
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