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(R)-(+)-Bay-K-8644
CAS No. 98791-67-4
(R)-(+)-Bay-K-8644( —— )
Catalog No. M37940 CAS No. 98791-67-4
(R)-(+)-Bay-K-8644 is a Ca2+ channel and dihydropyridine agonist that inhibits Ba2+ currents (IBa), induces central respiratory depression in cats, and inhibits platelet activation through competitive antagonism of thromboxane A2-prostaglandin H2 receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 94 | In Stock |
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| 2MG | 70 | In Stock |
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| 5MG | 117 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name(R)-(+)-Bay-K-8644
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NoteResearch use only, not for human use.
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Brief Description(R)-(+)-Bay-K-8644 is a Ca2+ channel and dihydropyridine agonist that inhibits Ba2+ currents (IBa), induces central respiratory depression in cats, and inhibits platelet activation through competitive antagonism of thromboxane A2-prostaglandin H2 receptors.
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Description(R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM).
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In Vitro(R)-(+)-Bay-K-8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist.Each optical isomer possesses opposite effects on IBa, (R)-(+)-Bay-K-8644 as an antagonist and S(-)-Bay K 8644 as an agonist. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM). When (R)-(+)-Bay-K-8644 (0.5 μM) is applied, IBa is suppressed to 71±10% of control.In the presence of (R)-(+)-Bay-K-8644IBa. (R)-(+)-Bay-K-8644 is a calcium channel inhibitor.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPPAR
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RecptorPPAR | Calcium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number98791-67-4
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Formula Weight356.3
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Molecular FormulaC16H15F3N2O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 300 mg/mL (841.99 mM)
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SMILESCOC(=O)C1=C(C)NC(C)=C([C@@H]1c1ccccc1C(F)(F)F)[N+]([O-])=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15.?
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