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Home - Products - Metabolic Enzyme/Protease - PPAR - (R)-(+)-Bay-K-8644

(R)-(+)-Bay-K-8644

CAS No. 98791-67-4

(R)-(+)-Bay-K-8644( —— )

Catalog No. M37940 CAS No. 98791-67-4

(R)-(+)-Bay-K-8644 is a Ca2+ channel and dihydropyridine agonist that inhibits Ba2+ currents (IBa), induces central respiratory depression in cats, and inhibits platelet activation through competitive antagonism of thromboxane A2-prostaglandin H2 receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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1 mL x 10 mM in DMSO 94 In Stock
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5MG 117 In Stock
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Biological Information

  • Product Name
    (R)-(+)-Bay-K-8644
  • Note
    Research use only, not for human use.
  • Brief Description
    (R)-(+)-Bay-K-8644 is a Ca2+ channel and dihydropyridine agonist that inhibits Ba2+ currents (IBa), induces central respiratory depression in cats, and inhibits platelet activation through competitive antagonism of thromboxane A2-prostaglandin H2 receptors.
  • Description
    (R)-(+)-Bay-K-8644 is a calcium channel inhibitor. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM).
  • In Vitro
    (R)-(+)-Bay-K-8644, a conventional racemic mixture of Bay K 8644, is widely used as an L-type Ca2+ channel agonist.Each optical isomer possesses opposite effects on IBa, (R)-(+)-Bay-K-8644 as an antagonist and S(-)-Bay K 8644 as an agonist. (R)-(+)-Bay-K-8644 inhibits Ba2+ currents (IBa) (IC50=975 nM). When (R)-(+)-Bay-K-8644 (0.5 μM) is applied, IBa is suppressed to 71±10% of control.In the presence of (R)-(+)-Bay-K-8644IBa. (R)-(+)-Bay-K-8644 is a calcium channel inhibitor.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    PPAR
  • Recptor
    PPAR | Calcium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    98791-67-4
  • Formula Weight
    356.3
  • Molecular Formula
    C16H15F3N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 300 mg/mL (841.99 mM)
  • SMILES
    COC(=O)C1=C(C)NC(C)=C([C@@H]1c1ccccc1C(F)(F)F)[N+]([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhu HL, et al. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15.?
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