Lactoferrin B( —— )

Catalog No. M37662 CAS No. 936541-36-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Lactoferrin B
Note

Research use only, not for human use.
Brief Description

Lactoferrin is secreted by mammals and displays extensive biological effects including boosting the cold tolerance of a well-applied probiotic strain.
Description

Lactoferrin is a substance released by neutrophils. Lactoferrin is an orally active multifunctional iron binding glycoprotein. Lactoferrin prevents cell adhesion, growth and spreading of cell colonies. Lactoferrin also has antiviral activity and inhibits microbial and viral adhesion and entry into host cells. Besides, Lactoferrin hasanti-inflammatory, immunomodulatory, and anti-cancer activities.
In Vitro

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In Vivo

Animal Model:Squamous cell carcinoma model (O12 cell injected into the left flank of nu/numice)Dosage:1,000 mg/kg Administration:oral gavage, twice daily for 8 days Result:Inhibited the tumor growth by 80%.Animal Model:Sepsis-induced acute lung injury rat modelDosage:100 and 200 mg/kg Administration:oral gavage,for 30 consecutive days Result:Reduced the wet/dry ratio of lung tissue by 30.7% and 61.3%, and lipid peroxidation by 22.3% and 67%, at concentrations of 100 and 200mg/kg. Reduced Inflammatory markers, neutrophils, lymphocytes and total cell count.
Synonyms

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Pathway

Proteasome/Ubiquitin
Target

Endogenous Metabolite
Recptor

Endogenous Metabolite
Research Area

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Indication

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1. P?ll?nen MT, et al. Lactoferrin impedes epithelial cell adhesion in vitro. J Periodontal Res. 1998 Jan;33(1):8-16.?

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