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Home - Products - Immunology/Inflammation - PD-1/PD-L1 - PD-1/PD-L1-IN-9

PD-1/PD-L1-IN-9

CAS No. 2628506-54-5

PD-1/PD-L1-IN-9( —— )

Catalog No. M37646 CAS No. 2628506-54-5

PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction. It enhances the immune cells' ability to kill tumor cells and demonstrates significant antitumor activity in vivo in a CT26 mouse model.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 84 Get Quote
5MG 129 Get Quote
10MG 188 Get Quote
25MG 305 Get Quote
50MG 415 Get Quote
100MG 536 Get Quote
500MG 1062 Get Quote
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Biological Information

  • Product Name
    PD-1/PD-L1-IN-9
  • Note
    Research use only, not for human use.
  • Brief Description
    PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction. It enhances the immune cells' ability to kill tumor cells and demonstrates significant antitumor activity in vivo in a CT26 mouse model.
  • Description
    PD-1/PD-L1-IN-9 is a potent and orally active inhibitor of PD-1/PD-L1 interaction, with an IC50 of 3.8 nM. PD-1/PD-L1-IN-9 can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 also exhibits significant in vivo antitumor activity in a CT26 mouse model.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male BALB/c mice (5-6 weeks) were inoculated CT26 cells Dosage:40 mg/kg, 80 mg/kg Administration:Oral gavage; once daily, for 2 weeks Result:Significantly decreased the final tumor weight, with TGI values of 60 and 67% at the dose of 40 and 80 mg/kg, respectively.Animal Model:Pharmacokinetic analysis in sprague-Dawley (SD) ratsDosage:3 mg/kg and 25 mg/kg Administration:Intravenous injection or oral gavage.
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    PD-1/PD-L1
  • Recptor
    PD-1/PD-L1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2628506-54-5
  • Formula Weight
    348.44
  • Molecular Formula
    C22H24N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (286.99 mM; Ultrasonic )
  • SMILES
    COc1nc(ccc1CNCCO)-c1cccc(c1C)-c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang T, et, al. Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2021 May 30.?
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