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PD-1/PD-L1-IN-9
CAS No. 2628506-54-5
PD-1/PD-L1-IN-9( —— )
Catalog No. M37646 CAS No. 2628506-54-5
PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction. It enhances the immune cells' ability to kill tumor cells and demonstrates significant antitumor activity in vivo in a CT26 mouse model.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 143 | In Stock |
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| 2MG | 78 | In Stock |
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| 5MG | 129 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 314 | In Stock |
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| 50MG | 419 | In Stock |
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| 100MG | 553 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1097 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePD-1/PD-L1-IN-9
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NoteResearch use only, not for human use.
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Brief DescriptionPD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction. It enhances the immune cells' ability to kill tumor cells and demonstrates significant antitumor activity in vivo in a CT26 mouse model.
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DescriptionPD-1/PD-L1-IN-9 is a potent and orally active inhibitor of PD-1/PD-L1 interaction, with an IC50 of 3.8 nM. PD-1/PD-L1-IN-9 can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 also exhibits significant in vivo antitumor activity in a CT26 mouse model.
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In Vitro——
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In VivoAnimal Model:Male BALB/c mice (5-6 weeks) were inoculated CT26 cells Dosage:40 mg/kg, 80 mg/kg Administration:Oral gavage; once daily, for 2 weeks Result:Significantly decreased the final tumor weight, with TGI values of 60 and 67% at the dose of 40 and 80 mg/kg, respectively.Animal Model:Pharmacokinetic analysis in sprague-Dawley (SD) ratsDosage:3 mg/kg and 25 mg/kg Administration:Intravenous injection or oral gavage.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetPD-1/PD-L1
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RecptorPD-1/PD-L1
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Research Area——
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Indication——
Chemical Information
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CAS Number2628506-54-5
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Formula Weight348.44
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Molecular FormulaC22H24N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (286.99 mM; Ultrasonic )
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SMILESCOc1nc(ccc1CNCCO)-c1cccc(c1C)-c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang T, et, al. Novel Biphenyl Pyridines as Potent Small-Molecule Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. J Med Chem. 2021 May 30.?
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