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BLU-263
CAS No. 2505078-08-8
BLU-263( —— )
Catalog No. M37619 CAS No. 2505078-08-8
BLU-263 is an investigational, potent, and selective oral small molecule inhibitor of KIT with sub-nanomolar potency against D816V-mutant KIT.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 141 | In Stock |
|
| 10MG | 226 | In Stock |
|
| 25MG | 434 | In Stock |
|
| 50MG | 556 | In Stock |
|
| 100MG | 798 | In Stock |
|
| 200MG | 1070 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBLU-263
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NoteResearch use only, not for human use.
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Brief DescriptionBLU-263 is an investigational, potent, and selective oral small molecule inhibitor of KIT with sub-nanomolar potency against D816V-mutant KIT.
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DescriptionElenestinib (BLU-263) is a potent and orally active tyrosine kinase inhibitor. Elenestinib has the potential for the research of systemic mastocytosis (SM). Elenestinib inhibits KIT D816V with an IC50 value of 0.2 nM.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayAngiogenesis
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Targetc-Kit
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Recptorc-Kit
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Research Area——
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Indication——
Chemical Information
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CAS Number2505078-08-8
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Formula Weight528.58
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Molecular FormulaC27H29FN10O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (236.48 mM; Ultrasonic )
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SMILESC[C@](N)(c1ccc(F)cc1)c1cnc(nc1)N1CCN(CC1)c1ncnn2cc(cc12)-c1cnn(CCO)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dave N, et al. Safety and pharmacokinetics of BLU-263, a next-generation KIT inhibitor, in healthy volunteers[C]//Cancer Res (AACR Annual Meeting Abstracts). 2021, 122.
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