CHMFL-KIT-031( —— )

Catalog No. M16977 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

CHMFL-KIT-031
Note

Research use only, not for human use.
Brief Description

CHMFL-KIT-031 is a highly selective KIT kinase primary V559D mutant inhibitor with IC50/Kd of 28/266 nM.
Description

CHMFL-KIT-031 is a highly selective KIT kinase primary V559D mutant inhibitor with IC50/Kd of 28/266 nM, 10-20 fold selectivity over KIT wt; also displays 15-400-fold selectivity over other primary mutants such as L576P and secondary mutants including T670I, V654A as well as N822K and D816V; exhibits a selectivity S score (1) of 0.01 among 468 kinases/mutants in the KINOMEScan assay; inhibits the proliferation of BaF3-TEL-KIT-V559D cells with IC50 of 25 nM, shows potent inhibitory efficacy for KIT V559D mediated signaling pathways in cell and anti-tumor activity in vivo.
In Vitro

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In Vivo

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Synonyms

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Pathway

Angiogenesis
Target

c-Kit
Recptor

c-Kit
Research Area

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Indication

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CAS Number

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Formula Weight

487.516
Molecular Formula

C26H25N5O5
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(E)-3,4,5-trimethoxy-N-(2-oxo-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)ethyl)benzamide

1. Yu K, et al. Oncotarget. 2017 Nov 15;8(67):111110-111118.

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