6-Diazo-5-oxo-L-nor-Leucine

Research use only, not for human use.

6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is a glutaminase antagonist (Ki: 6 μM) and an antineoplastic antibiotic produced by an unidentified Streptomyces species from Peruvian soil.

6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine; DON) is a glutamine antagonist that irreversibly inhibits the catabolic effect of glutamine. 6-Diazo-5-oxo-L-nor-Leucine shows good anticancer activity (especially in pancreatic cancer) and reduces the self-renewal potential and metastatic capacity of tumour cells. 6-Diazo-5-oxo-L-nor-Leucine also possesses antibacterial and antiviral activity.

6-Diazo-5-oxo-L-nor-Leucine (DON) (0.3 mM; 1 h) shows inhibition of glutamine catabolism in WI-L2 cells.?6-Diazo-5-oxo-L-nor-Leucine (DON) decreases the selfrenewal potential and metastatic ability of tumor cell.Cell Viability Assay Cell Line:WI-L2 cells Concentration:0.3 mM Incubation Time:1 h Result:Inhibited the rapid catabolism of glutamine by the cultured human lymphoblast line WI-L2 greater than 95%.

6-Diazo-5-oxo-L-nor-Leucine sensitizes pancreatic tumors to anti-PD1 resulting in tumor regression and prolonged survival in vivo.6-Diazo-5-oxo-L-nor-Leucine decreases hyaluronan and collagen in the tumor microenvironment, leading to an extensive remodeling of the ECM (extensive extracellular matrix), and an increases infiltration CD8+ T-cells.

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Others

Other Targets

Glutaminase | Influenza Virus | Antibiotic | Antibacterial

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157-03-9

171.15

C6H9N3O3

>98% (HPLC)

In Vitro:?H2O : 25 mg/mL (146.07 mM; Ultrasonic)

N[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years