2-Deoxy-D-galactose( —— )

Catalog No. M37322 CAS No. 1949-89-9

2-Deoxy-D-galactose is a glucose analog and glucose antagonist that inhibits the maintenance of hippocampal LTP and can suppress tumor growth by inhibiting the glycolytic process.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

2-Deoxy-D-galactose
Note

Research use only, not for human use.
Brief Description

2-Deoxy-D-galactose is a glucose analog and glucose antagonist that inhibits the maintenance of hippocampal LTP and can suppress tumor growth by inhibiting the glycolytic process.
Description

2-Deoxy-D-galactose is a glucose analog. 2-Deoxy-D-galactose inhibits glycolysis to inhibits tumor growth. 2-Deoxy-D-galactose is a substance interfering with the fucosylation of glycomacromolecules and impairing memory consolidation in various learning tasks. 2-Deoxy-d-galactose hinders glycoprotein fucosylation in vivo.
In Vitro

2-Deoxy-D-galactose (1 mM/L; 5 h) is rapid phosphorylation during the first 30 min and decreases to approximately 20% of this rate during the subsequent hours in ascites hepatoma cells.
In Vivo

2-Deoxy-D-galactose (380 mg/kg; i.p.; for 6 times) strongly decreases contents of UMP, UDPG, and UDP galactose in rat livers.2-Deoxy-D-galactose (2-8 μM; intracerebroventricularly injection; once) shows PAR impairment 30 min before the acquisition trial a dose of 4 μM and 15 min delay after do-gal administration.Animal Model:Male adult Wistar rats with passive avoidance response (PAR) acquisition trial Dosage:2, 4 and 8 μM Administration:Intracerebroventricularly injection; 2-8 μM; once Result:Exhibited PAR disruption at a dose of 4 μM.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

1949-89-9
Formula Weight

164.16
Molecular Formula

C6H12O5
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 250 mg/mL (1522.90 mM; Ultrasonic) Methanol : 125 mg/mL (761.45 mM; Ultrasonic)
SMILES

OC[C@@H](O)[C@H](O)[C@H](O)CC=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Keppler DO, et al. The trapping of uridine phosphates by D-galactosamine. D-glucosamine, and 2-deoxy-D-galactose. A study on the mechanism of galactosamine hepatitis. Eur J Biochem. 1970 Dec;17(2):246-53.?

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