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FIDAS-5
CAS No. 1391934-98-7
FIDAS-5( —— )
Catalog No. M22933 CAS No. 1391934-98-7
FIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities. FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM.FIDAS-5 induces the expression of cell cycle inhibitor, p21WAF1/CIP1. FIDAS-5 (3 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells.FIDAS-5 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 73 | In Stock |
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| 5MG | 112 | In Stock |
|
| 10MG | 186 | In Stock |
|
| 25MG | 332 | In Stock |
|
| 50MG | 500 | In Stock |
|
| 100MG | 724 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1386 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameFIDAS-5
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NoteResearch use only, not for human use.
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Brief DescriptionFIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities. FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM.FIDAS-5 induces the expression of cell cycle inhibitor, p21WAF1/CIP1. FIDAS-5 (3 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells.FIDAS-5 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells.
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DescriptionFIDAS-5 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-5 has anticancer activities. FIDAS-5 is a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM.FIDAS-5 induces the expression of cell cycle inhibitor, p21WAF1/CIP1. FIDAS-5 (3 μM; 36 h) treatment reduces the levels of both S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in LS174T cells.FIDAS-5 (3 μM; 7 days; LS174T cells) treatment significantly inhibits the proliferation of LS174T cells. FIDAS-5 (3 μM) treatment inhibits the expression of c-Myc and cyclinD1 in LS174T CRC cells. Mice are treated with FIDAS-5 (20 mg/kg) for 1 week. The liver SAM levels are significantly reduced.FIDAS-5 (20 mg/kg; oral gavage; daily; for two weeks; athymic nude mice) treatment significantly inhibits the growth of xenograft tumors, with minimal difference in body weight.
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In VitroCell Viability Assay Cell Line:LS174T colorectal cancer (CRC) cells Concentration:3 μM Incubation Time:7 days Result:Significantly inhibited the proliferation of LS174T cells.
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In VivoAnimal Model:16 athymic nude mice injected with HT29 CRC cellsDosage:20 mg/kg Administration:Oral gavage; daily; for two weeks Result:Significantly inhibited the growth of xenograft tumors.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMAT2A
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Research Area——
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Indication——
Chemical Information
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CAS Number1391934-98-7
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Formula Weight261.72
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Molecular FormulaC15H13ClFN
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (477.61 mM; Need ultrasonic)
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SMILESCNC1=CC=C(/C=C/C2=C(F)C=CC=C2Cl)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang W, et al. Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A. ACS Chem Biol. 2013 Apr 19;8(4):796-803.
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