ALK-IN-27( —— )

Catalog No. M37318 CAS No. 2739866-40-9

Neladalkib (NVL-655) is a selective and brain-permeable ALK inhibitor with antitumor activity that inhibits a variety of ALK-mutant oncoproteins, and may be useful in the study of non-small cell cancers.

Purity : >98% (HPLC)

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Datasheet

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Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	141	In Stock
5MG	118	In Stock
10MG	188	In Stock
25MG	347	In Stock
50MG	517	In Stock
100MG	Get Quote	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

ALK-IN-27
Note

Research use only, not for human use.
Brief Description

Neladalkib (NVL-655) is a selective and brain-permeable ALK inhibitor with antitumor activity that inhibits a variety of ALK-mutant oncoproteins, and may be useful in the study of non-small cell cancers.
Description

ALK-IN-27 (compound 1) is a potent ALK inhibitor. ALK-IN-27 shows antitumor activity. ALK-IN-27 has an IC50 of 2.7 nM for Ba/F3 CLIP1-LTK cell.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

ALK
Recptor

ALK
Research Area

——
Indication

——

Chemical Information

CAS Number

2739866-40-9
Formula Weight

452.91
Molecular Formula

C23H22ClFN6O
Purity

>98% (HPLC)
Solubility

——
SMILES

C(C)N1C2=C(CC=3C(C=4C([C@@H](C)OC=5C=C2C=NC5N)=CC(F)=CC4)=NN(C)C3)C(Cl)=N1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Jennifer Anne Green, et al. Methods of treating solid tumor using (19r)-5-chloro-3-ethyl-16-fluoro-10,19-dimethyl-20-oxa-3,4,10,11,23-pentaazapentacyclo[19.3.1.02,6.08,12.013,18]pentacosa-1(24),2(6),4,8,11,13,15,17,21(25),22-decaen-22-amine. WO2023196910A1.

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