Cart
sales@molnova.com
RLY-2608
CAS No. 2733573-94-7
RLY-2608( —— )
Catalog No. M37293 CAS No. 2733573-94-7
RLY-2608 is a selective mutant PI3Kα inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 1359 | In Stock |
|
| 5MG | 1017 | In Stock |
|
| 10MG | 1644 | In Stock |
|
| 25MG | 2451 | In Stock |
|
| 50MG | 3236 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameRLY-2608
-
NoteResearch use only, not for human use.
-
Brief DescriptionRLY-2608 is a selective mutant PI3Kα inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.
-
DescriptionRLY-2608 is a first-in-class allosteric mutant-selective inhibitor of PI3Ka.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayPI3K/Akt/mTOR signaling
-
TargetPI3K
-
RecptorPI3K
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2733573-94-7
-
Formula Weight608.91
-
Molecular FormulaC29H14ClF5N6O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESN(C(=O)C1=CC(C(F)(F)F)=CC(F)=C1)C2=C3[C@@H](NC(=O)C3=CC(=C2)C4=C(C#N)N5C(C=C4)=NC=N5)C6=C(Cl)C=CC(F)=C6
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Andreas Varkaris, et al. Discovery and clinical proof-of-concept of RLY-2608, a first-in-class mutant-selective allosteric PI3Ka inhibitor that decouples anti-tumor activity from hyperinsulinemia. Cancer Discov. 2023 Nov 2.?
molnova catalog
related products
-
mTOR inhibitor 9d
mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia, skin cancer, breast cancer, lung cancer and colon cancer.
-
AMG 511
AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively).
-
PI3K inhibitor X
PI3K inhibitor X (XL-147 analog) is a derivative of XL147 that acts as a reversible inhibitor.
