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Nrf2 activator-3
CAS No. 2766570-23-2
Nrf2 activator-3( —— )
Catalog No. M37206 CAS No. 2766570-23-2
Nrf2 activator-3 is a potent Nrf2 activator with potential anti-inflammatory, antioxidant, and anti-tumor activities, suitable for studying neurological and immune-related diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 377 | In Stock |
|
| 10MG | 588 | In Stock |
|
| 25MG | 1197 | In Stock |
|
| 50MG | 1516 | In Stock |
|
| 100MG | 1841 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNrf2 activator-3
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NoteResearch use only, not for human use.
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Brief DescriptionNrf2 activator-3 is a potent Nrf2 activator with potential anti-inflammatory, antioxidant, and anti-tumor activities, suitable for studying neurological and immune-related diseases.
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DescriptionNrf2 activator-3 is a potent Nrf2 activator. Nrf2 activator-3 is used for cerebral ischemic injury research.
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In VitroCell Viability Assay Cell Line:PC12 cell Concentration:1 μM, 5 μM, and 10 μM Incubation Time:Result:Alleviated SNP-induced apoptosis in a concentration-dependent manner.
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In VivoAnimal Model:MCAO rats Dosage:3 mg/kg; 10 mg/kg; 30 mg/kg Administration:Intraperitoneal injection Result:Attenuated cerebral ischemic injury.(low dose: 16.37 ± 6.51%, medium dose: 14.49 ± 5.62%, high dose: 12.23 ± 8.50%), which was similar to the effect of Edaravone (12.77 ± 5.82%).Animal Model:MCAO rats Dosage:3 mg/kg; 10 mg/kg; 30 mg/kg Administration:Intraperitoneal injection Result:Attenuated cerebral ischemic injury.(low dose: 16.37 ± 6.51%, medium dose: 14.49 ± 5.62%, high dose: 12.23 ± 8.50%), which was similar to the effect of Edaravone (12.77 ± 5.82%).
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Synonyms——
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PathwayOthers
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TargetAntioxidant
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RecptorAntioxidant | Nrf2
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Research Area——
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Indication——
Chemical Information
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CAS Number2766570-23-2
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Formula Weight425.4
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Molecular FormulaC23H18F3N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESFC(F)(F)C=1C=CC(=C(O)C1)C=2N=C(C=3C=CC=CC3O)N(N2)C=4C=C(C=C(C4)C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yaoqiang Lao, et al. Synthesis and biological evaluation of 1,2,4-triazole derivatives as potential Nrf2 activators for the treatment of cerebral ischemic injury. Eur J Med Chem. 2022 Jun 5;236:114315.?
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