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STX-478
CAS No. 2883540-92-7
STX-478( —— )
Catalog No. M37154 CAS No. 2883540-92-7
STX-478 is an orally active and selective PI3Kα inhibitor that penetrates the blood-brain barrier and has anticancer activity to inhibit tumor growth.STX-478 is indicated for the study of breast cancer and other cancers.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 514 | Get Quote |
|
| 5MG | 816 | Get Quote |
|
| 10MG | 1292 | Get Quote |
|
| 25MG | 2548 | Get Quote |
|
| 50MG | 4076 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSTX-478
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NoteResearch use only, not for human use.
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Brief DescriptionSTX-478 is an orally active and selective PI3Kα inhibitor that penetrates the blood-brain barrier and has anticancer activity to inhibit tumor growth.STX-478 is indicated for the study of breast cancer and other cancers.
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DescriptionSTX-478 (compound 80) is an oral CNS-penetrant allosteric mutant-selective PI3Kα inhibitor. STX-478 shows robust and durable tumor regression and can be used in cancer research.
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In VitroImmunofluorescence Cell Line:MCF10A cells Concentration:0-10,000 nM Incubation Time:1 h Result:Targeted the MCF10A cells (with the H1047R kinase domain mutation).
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In VivoAnimal Model:Female BALB/c nude mice (CAL-33 xenograft model).Dosage:30, 100 mg/kg Administration:Oral administration Result:Showed a dose-dependent reduction in tumor volume.
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research Area——
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Indication——
Chemical Information
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CAS Number2883540-92-7
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Formula Weight401.29
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Molecular FormulaC16H12F5N5O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (622.99 mM; Ultrasonic )
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SMILES[C@H](NC(NC=1C=NC(N)=NC1)=O)(C(F)(F)F)C2=C(C)C=3C(O2)=C(F)C=C(F)C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. JR David St Jean, et al. Urea derivatives which can be used to treat cancer. Patent WO2022265993A1.
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