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Tz-Thalidomide
CAS No. 2087490-42-2
Tz-Thalidomide( —— )
Catalog No. M37130 CAS No. 2087490-42-2
Tz-Thalidomide is a tetrazine-modified Thalidomide (E3 ligase ligand) with some affinity for BRD4.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 115 | In Stock |
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| 5MG | 86 | In Stock |
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| 10MG | 141 | In Stock |
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| 25MG | 285 | In Stock |
|
| 50MG | 448 | In Stock |
|
| 100MG | 703 | In Stock |
|
| 200MG | 939 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTz-Thalidomide
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NoteResearch use only, not for human use.
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Brief DescriptionTz-Thalidomide is a tetrazine-modified Thalidomide (E3 ligase ligand) with some affinity for BRD4.
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DescriptionTz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2). Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetEpigenetic Reader Domain
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RecptorEpigenetic Reader Domain
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Research Area——
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Indication——
Chemical Information
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CAS Number2087490-42-2
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Formula Weight571.58
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Molecular FormulaC29H29N7O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (87.48 mM; Ultrasonic )
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SMILESO=C1NC(=O)C(N2C(=O)C=3C=CC=C(OCCCCCC(=O)NCC=4C=CC(=CC4)C5=NN=C(N=N5)C)C3C2=O)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lebraud H, et al. Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras. ACS Cent Sci. 2016 Dec 28;2(12):927-934.?
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