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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - Cyclogalegenol

Cyclogalegenol

CAS No. 78574-94-4

Cyclogalegenol( Astramembrangenin )

Catalog No. M20292 CAS No. 78574-94-4

Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cyclogalegenol
  • Note
    Research use only, not for human use.
  • Brief Description
    Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression.
  • Description
    Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression.
  • In Vitro
    Cycloastragenol (0.03-3 μM; 24-72 hours) promotes viability, osteoblastic differentiation, and mineralization in MC3T3-E1 cells.
  • In Vivo
    Cycloastragenol (5, 10, 20 mg/kg) is injected intraperitoneally at the onset of reperfusion, 12 h later and then twice daily for up to three days. Cycloastragenol dose-dependently reduces brain infarct volume, significantly ameliorated functional deficits, and prevents neuronal cell loss in middle cerebral artery occlusion (MCAO) mice. Cycloastragenol suppresses the mRNA expression of pro-inflammatory cytokines, including TNF-α and IL-1β, and inhibits the activation of microglia and astrocytes in the ischemic brain.
  • Synonyms
    Astramembrangenin
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    CREB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    78574-94-4
  • Formula Weight
    490.72
  • Molecular Formula
    C30H50O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:98 mg/mL (199.71 mM)
  • SMILES
    [H][C@@]1([C@@H](O)C[C@@]2(C)[C@]3([H])C[C@H](O)[C@]4([H])[C@]5(C[C@@]35CC[C@]12C)CC[C@H](O)C4(C)C)[C@@]1(C)CC[C@H](O1)C(C)(C)O
  • Chemical Name
    (2aR3R4S5aS5bS7S7aR9S11aR12aS)-3-((2R5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a5a88-tetramethyltetradecahydro-1H12H-cyclopenta[a]cyclopropa[e]phenanthrene-479-triol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sun C Jiang M Zhang L et al. Cycloastragenol mediates activation and proliferation suppression in concanavalin A-induced mouse lymphocyte pan-activation model[J]. Immunopharmacology and Immunotoxicology 2017 39(3):131-139.
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