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hCYP3A4 Fluorogenic substrate 1
CAS No. 186299-00-3
hCYP3A4 Fluorogenic substrate 1( —— )
Catalog No. M37062 CAS No. 186299-00-3
hCYP3A4 Fluorogenic substrate 1, a phthalimide derivative, exhibits low activity against COX.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 70 | In Stock |
|
| 5MG | 117 | In Stock |
|
| 10MG | 187 | In Stock |
|
| 25MG | 376 | In Stock |
|
| 50MG | 585 | In Stock |
|
| 100MG | 918 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1841 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamehCYP3A4 Fluorogenic substrate 1
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NoteResearch use only, not for human use.
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Brief DescriptionhCYP3A4 Fluorogenic substrate 1, a phthalimide derivative, exhibits low activity against COX.
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DescriptionhCYP3A4 Fluorogenic substrate 1 is a potrnt hCYP3A4 fluorogenic substrate with an Km value of 0.36 μM. hCYP3A4 Fluorogenic substrate 1 can be used for cell and in vivo imaging.
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In Vitro——
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In VivoAnimal Model:Male Sprague-Dawley ratsDosage:10 mg/kg Administration:I.v.Result:Can be used as a probe substrate offers a highly efficient and easy-to-use approach for screening and characterizing hCYP3A4 inhibitors or time-dependent inactivators, which strongly facilitates hCYP3A4-mediated DDI studies.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX
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Research Area——
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Indication——
Chemical Information
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CAS Number186299-00-3
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Formula Weight305.3
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Molecular FormulaC19H12FNO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 12.5 mg/mL (40.94 mM; Ultrasonic (<60°C)
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SMILESO=C1C=2C=3C(C(=O)N1CC4=CC=C(F)C=C4)=CC=CC3C=CC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. He RJ, et al. Rationally Engineered CYP3A4 Fluorogenic Substrates for Functional Imaging Analysis and Drug-Drug Interaction Studies. J Med Chem. 2023 May 25;66(10):6743-6755.?
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