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Hexahydrocurcumin
CAS No. 36062-05-2
Hexahydrocurcumin( —— )
Catalog No. M24319 CAS No. 36062-05-2
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 311 | In Stock |
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| 5MG | 188 | In Stock |
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| 10MG | 312 | In Stock |
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| 25MG | 629 | In Stock |
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| 50MG | 918 | In Stock |
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| 100MG | 1293 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHexahydrocurcumin
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NoteResearch use only, not for human use.
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Brief DescriptionHexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
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DescriptionHexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
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In VitroHexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) treatment significantly decreased the viability of HT-29 colon cancer cells in a time- and concentration-dependent. The respective IC50 values for 24 and 48 h of Hexahydrocurcumin exposureare 77.05 and 56.95, respectively.Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 μM) markedly reduces the COX-2 expression. The level of COX-1 is not altered.Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 μM) markedly reduces the COX-2 protein. The level of COX-1 protein is not altered.Hexahydrocurcumin (7-14 μM; 24 hours) attenuates lipopolysaccharide (LPS)-elicited increase of prostaglandin E2 (PGE2) in murine macrophages (RAW 264.7) in a concentration-dependent manner. Cell Viability Assay Cell Line:HT-29 cells Concentration:0 μM, 5 μM, 10 μM, 25 μM Incubation Time:24 hours or 48 hours Result:Significantly decreased the viability of HT-29 colon cancer cells.RT-PCR Cell Line:HT-29 cells Concentration:25 μM Incubation Time:24 hours Result:Combined with 5-fluorouracil (5-FU; 5 μM) markedly reduced the COX-2 expression.Western Blot Analysis Cell Line:HT-29 cells Concentration:25 μM Incubation Time:24 hours Result:Combined with 5-fluorouracil (5-FU; 5 μM) markedly reduced the COX-2 protein.
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In VivoHexahydrocurcumin (50 mg/kg; oral administration; daily; for 16 weeks; male Wistar rats) treatment significantly reduces the numbers of aberrant crypt foci (ACF) in colon cancer rats. Hexahydrocurcumin also markedly decreases COX-2 protein expression. The levels of COX-1 protein is not different from normal rats. Animal Model:Male Wistar rats (100-120 g) injected with dimethylhydrazine (DMH) Dosage:50 mg/kg Administration:Oral administration; daily; for 16 weeks Result:Significantly reduced the numbers of ACF in colon cancer rats. Also markedly decreased COX-2 protein expression.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX-1|ROS
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Research Area——
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Indication——
Chemical Information
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CAS Number36062-05-2
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Formula Weight374.43
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Molecular FormulaC21H26O6
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Purity>98% (HPLC)
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SolubilityDMSO:45 mg/mL (120.19 mM; Need ultrasonic)
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SMILESO=C(CC(O)CCC1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C(OC)=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Srimuangwong K, et al. Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells. World J Gastroenterol. 2012 May 21;18(19):2383-9.
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