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Enpp/Carbonic?anhydrase-IN-2
Enpp/Carbonic?anhydrase-IN-2
CAS No. 2883495-39-2
Enpp/Carbonic?anhydrase-IN-2( —— )
Catalog No. M37002 CAS No. 2883495-39-2
Enpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 98 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 148 | In Stock |
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| 25MG | 250 | In Stock |
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| 50MG | 349 | In Stock |
|
| 100MG | 476 | In Stock |
|
| 200MG | 642 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameEnpp/Carbonic?anhydrase-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionEnpp/Carbonic anhydrase-IN-2 is a potent dual inhibitor of Enpp and carbonic anhydrase, inhibiting NPP1, NPP2, NPP3, CA-IX, CA-XII, with IC50 values of 1.13, 1.07, 0.74, 0.33, 0.68, respectively.
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DescriptionEnpp/Carbonic anhydrase-IN-2 (compound 1i) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic anhydrase-IN-2 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-2 induces Apoptosis.
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In VitroEnpp/Carbonic anhydrase-IN-2 (compound 1i) (0-100 μM; ) inhibits some cancer cells growth with IC50s of 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, 0.83 μM for K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, T-47D cells, respectively.Enpp/Carbonic anhydrase-IN-2 (0-2 μM) shows low cytotoxic against normal breast epithelial cells (HME1) and normal skin fibroblast cells (F180) with IC50s of > 50 μM.Enpp/Carbonic anhydrase-IN-2 (0.58, 1.16 μM) induces apoptosis in a dose-dependent manner at K-562 cells.Cell Proliferation Assay Cell Line:K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, T-47D cells Concentration:0-100 μM Incubation Time:Result:Inhibited the cell growth with IC50s of 0.58, 0.58, 0.63, 0.42, 0.20, 0.72, 0.41, 0.76, 0.94, 0.28, 0.49, 0.59, 0.83 μM for K-562, COLO 205, HCT-116, HCT-15, HT29, KM12, SW-620, SF-539, NCI/ADR-RES, A498, PC-3, MCF7, T-47D cells, respectively.Apoptosis Analysis Cell Line:K-562 cells Concentration:0.58, 1.16 μM Incubation Time:Result:Induced apoptosis in a dose-dependent manner.
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetCarbonic Anhydrase
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RecptorCarbonic Anhydrase | Apoptosis | PDE
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Research Area——
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Indication——
Chemical Information
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CAS Number2883495-39-2
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Formula Weight429.5
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Molecular FormulaC23H24FNO4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (232.83 mM; Ultrasonic )
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SMILESC(NC1=CC=C(OS(=O)(=O)C2=CC=C(F)C=C2)C=C1)(=O)C34CC5CC(C3)CC(C4)C5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Afnan I.Shahin, et al. Design and synthesis of new adamantyl derivatives as promising antiproliferative agents. European Journal of Medicinal Chemistry, 2022.
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