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hCAIX-IN-5

CAS No. 2451479-57-3

hCAIX-IN-5( —— )

Catalog No. M35467 CAS No. 2451479-57-3

hCAIX-IN-5 was a selective hCAIX inhibitor, inhibiting hCAI, hCAII, hCAIV, and hCAIX with Ki values of >10000, >10000, 130.7, and 829.1 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    hCAIX-IN-5
  • Note
    Research use only, not for human use.
  • Brief Description
    hCAIX-IN-5 was a selective hCAIX inhibitor, inhibiting hCAI, hCAII, hCAIV, and hCAIX with Ki values of >10000, >10000, 130.7, and 829.1 nM, respectively.
  • Description
    hCAIX-IN-5 (compound 6b) is a potent and selective hCAIX inhibitor with KIs of >10000, >10000, 130.7, 829.1 nM for hCAI, hCAII, hCAIV, hCAIX, respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Carbonic Anhydrase
  • Recptor
    Carbonic Anhydrase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2451479-57-3
  • Formula Weight
    309.29
  • Molecular Formula
    C18H12FNO3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N(C(/C=C/C1=CC=C(F)C=C1)=O)C=2C=C3C(=CC2)OC(=O)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Swain B, et al. New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation. Bioorg Med Chem. 2020 Aug 1;28(15):115586.?
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