Dimethylfraxetin( 678-Trimethoxycoumarin | Fraxetin dimethyl ether )

Catalog No. M20278 CAS No. 6035-49-0

Dimethylfraxetin is a Carbonic anhydrase inhibitor（Ki：0.0097 μM）

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Dimethylfraxetin
Note

Research use only, not for human use.
Brief Description

Dimethylfraxetin is a Carbonic anhydrase inhibitor（Ki：0.0097 μM）
Description

Dimethylfraxetin is a Carbonic anhydrase inhibitor.（Ki：0.0097 μM）.
In Vitro

At CA I there is one stand out compound being Dimethylfraxetin (compound 17), a nanomolar CA I inhibitor. This trimethoxy coumarin is the most potent of any of the NP coumarins across the six CA isozymes of the present study.
In Vivo

——
Synonyms

678-Trimethoxycoumarin | Fraxetin dimethyl ether
Pathway

Membrane Transporter/Ion Channel
Target

Carbonic Anhydrase
Recptor

Carbonic Anhydrase
Research Area

——
Indication

——

Chemical Information

CAS Number

6035-49-0
Formula Weight

236.22
Molecular Formula

C12H12O5
Purity

>98% (HPLC)
Solubility

DMSO:125 mg/mL?(529.17 mM)
SMILES

COc1cc2ccc(=O)oc2c(OC)c1OC
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Davis R A Vullo D Maresca A et al. Natural product coumarins that inhibit human carbonic anhydrases[J]. Bioorganic & medicinal chemistry 2012 21(6):1539-1543.

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