Disulfamide

Research use only, not for human use.

Disulfamide is an orally active carbonic anhydrase inhibitor with an IC50 value of 0.07 μM. Disulfamide has a diuretic effect by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal convoluted tubules.

Disulfamide, an orally active diuretic, is a carbonic anhydrase inhibitor with the IC50 value of 0.07 μM. Disulfamide leads to diuresis by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal tubule.

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Disulfamide (intraperitoneal injection, 200 mg/kg, once) has potential blood glucose raising properties in male Wistar rats.Animal Model:Male Wistar rats weighing between 200-300 g Dosage:200 mg/kg Administration: Intraperitoneal injection; once Result:Resulted in elevated blood sugar levels from an initial blood glucose concentration of 143.1 mg/100 mL to a one hour later final concentration of 194.6 mg/100 mL, an increase of 36%.

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Membrane Transporter/Ion Channel

Carbonic Anhydrase

Carbonic Anhydrase

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671-88-5

284.74

C7H9ClN2O4S2

>98% (HPLC)

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S(N)(=O)(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1C

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(-20℃)

With Ice Pack

≥ 2 years