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Nemvaleukin alfa
CAS No. 2315268-27-8
Nemvaleukin alfa( —— )
Catalog No. M36815 CAS No. 2315268-27-8
Nemvaleukin alfa (ALKS 4230) is an interleukin 2 fusion protein, a selective agonist of the medium-affinity IL-2 receptor, produced by fusion of the IL-2Ralpha subunit of the circularly arranged interleukin-2 (IL-2) and IL-2 receptor (IL-2R) complexes, which drives antitumor Immunity and inhibits tumor growth in small cell lung cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1017 | In Stock |
|
| 10MG | 1634 | In Stock |
|
| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNemvaleukin alfa
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NoteResearch use only, not for human use.
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Brief DescriptionNemvaleukin alfa (ALKS 4230) is an interleukin 2 fusion protein, a selective agonist of the medium-affinity IL-2 receptor, produced by fusion of the IL-2Ralpha subunit of the circularly arranged interleukin-2 (IL-2) and IL-2 receptor (IL-2R) complexes, which drives antitumor Immunity and inhibits tumor growth in small cell lung cancer.
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DescriptionNemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer.
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In Vitro——
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In VivoAnimal Model:SCLC orthotopic model Dosage:6 mg/kg Administration:s.c., every 4?days Result:Delayed tumor growth and prolonged survival. Animal Model:Male cynomolgus monkeys (PK Assay) Dosage:0.3 or 1 mg/kg Administration:i.v. or s.c.Result:Pharmacokinetic profile of Nemvaleukin alfa.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorInterleukin
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Research Area——
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Indication——
Chemical Information
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CAS Number2315268-27-8
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Formula Weight
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pan Y, et al, a novel engineered IL-2 fusion protein, drives antitumor immunity and inhibits tumor growth in small cell lung cancer. J Immunother Cancer. 2022 Sep;10(9):e004913. ?
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