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Leronlimab

CAS No. 674782-26-4

Leronlimab( —— )

Catalog No. M36806 CAS No. 674782-26-4

Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody with both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronlimab can be used to study HIV, non-alcoholic steatohepatitis (NASH), and breast cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Leronlimab
  • Note
    Research use only, not for human use.
  • Brief Description
    Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody with both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronlimab can be used to study HIV, non-alcoholic steatohepatitis (NASH), and breast cancer.
  • Description
    Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. Leronlimab inhibits CCR5-mediated HIV-1 viral and lung metastasis in mouse tumor models. Leronlimab can be used for the research of HIV nonalcoholic steatohepatitis (NASH) and cancer.
  • In Vitro
    Cell Cytotoxicity Assay Cell Line:MDA-MB-231 cell line Concentration:10 μg/mL Incubation Time:72 hours Result:Increased the cells killing effect induced by doxorubicin.
  • In Vivo
    Animal Model:Female NCI Athymic nu/nu nude mice with MB-MDA-231 cells expressing Luc2-eGFP injection Dosage:2 mg Administration:Intraperitoneal injection; 2 mg, twice a week Result:Reduced the volume of pulmonary metastases at 8 weeks.
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    CCR
  • Recptor
    CCR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    674782-26-4
  • Formula Weight
  • Molecular Formula
    ——
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Jiao X, et al. Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. Breast Cancer Res. 2021 Jan 23;23(1):11.?
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