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SB 297006
CAS No. 58816-69-6
SB 297006( —— )
Catalog No. M19378 CAS No. 58816-69-6
SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 30 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 44 | In Stock |
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| 25MG | 93 | In Stock |
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| 50MG | 138 | In Stock |
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| 100MG | 207 | In Stock |
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| 200MG | 309 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSB 297006
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NoteResearch use only, not for human use.
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Brief DescriptionSB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.
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DescriptionSB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg).
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In VitroSB297006 is a CCR3 antagonist, significantly inhibits proliferation and neurosphere formation in CCL11-treated neural progenitor cells (NPCs) at 100 μM.
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetCCR
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RecptorCCR3
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Research Area——
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Indication——
Chemical Information
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CAS Number58816-69-6
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Formula Weight342.4
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Molecular FormulaC18H18N2O5
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Purity>98% (HPLC)
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SolubilityDMSO : 150 mg/mL 438.15 mM;H2O : < 0.1 mg/mL
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SMILESO=[N+]([O-])c2ccc(C[C@H](NC(=O)c1ccccc1)C(=O)OCC)cc2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Mori, A., Ogawa, K., Someya, K., et al. Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists. Int. Immunol. 19(8), 913-921 (2007).
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