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Narsoplimab
CAS No. 2108782-45-0
Narsoplimab( —— )
Catalog No. M36752 CAS No. 2108782-45-0
Narsoplimab (OMS 721) is a selective whole-human immunoglobulin gamma-4 (IgG4) monoclonal antibody and a mannan-binding lectin-associated serine protease-2 (MASP-2) inhibitor that binds MASP-2 to prevent lectin pathway activation and inhibit the agglutinin pathway.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 660 | In Stock |
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| 10MG | 1017 | In Stock |
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| 25MG | 1511 | In Stock |
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| 50MG | 2000 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameNarsoplimab
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NoteResearch use only, not for human use.
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Brief DescriptionNarsoplimab (OMS 721) is a selective whole-human immunoglobulin gamma-4 (IgG4) monoclonal antibody and a mannan-binding lectin-associated serine protease-2 (MASP-2) inhibitor that binds MASP-2 to prevent lectin pathway activation and inhibit the agglutinin pathway.
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DescriptionNarsoplimab (OMS 721) is a high-affinity fully human immunoglobulin gamma 4 (IgG4) monoclonal antibody that binds MASP-2 and blocks lectin pathway activation. Narsoplimab can be used in research of hematopoietic stem-cell transplantation and SARS-CoV-2.
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In Vitro——
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In VivoAnimal Model:WT and Masp2-/- (KO) mice (C57BL/6N, female, 12-15 weeks old)Dosage:10 mg/kg Administration:Intravenous injection Result:Decreased percentage of lymphocytes (Lym%) and an increased percentage of neutrophils (Neu%).
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorSARS-CoV
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Research Area——
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Indication——
Chemical Information
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CAS Number2108782-45-0
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Formula Weight
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gao T, et, al. Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation. Signal Transduct Target Ther. 2022 Sep 14;7(1):318.?
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