Emibetuzumab

Research use only, not for human use.

Emibetuzumab is a potent humanized bivalent MET antibody (IgG4 type). Emibetuzumab has antitumor activity, inhibition of HGF-dependent and independent MET pathway activation and tumor growth, and can be used to study advanced castration-resistant prostate cancer.

Emibetuzumab (LY2875358) is a humanized bivalent MET antibody (IgG4 type). Emibetuzumab shows high neutralization and internalization activities, resulting in inhibition of both HGF-dependent and HGF-independent MET pathway activation and tumor growth. Emibetuzumab can be used in study of cancer.

Emibetuzumab (LY2875358) (100 nmol/L; 6 days) inhibits HGF-stimulated proliferation of H596.Cell Proliferation Assay Cell Line:H596 cells (HGF-stimulated) Concentration:100 nmol/L Incubation Time:6 days Result:Suppressed cell proliferation.

Emibetuzumab (LY2875358) (10 mg/kg; i.v.; once a week for 5 weeks) inhibits in vivo growth of glioblastoma U87MG xenograft tumors in mice.Emibetuzumab (10 or 20 mg/kg; i.v.; single) downregulates levels of MET and pMET in the tumors of mice.Emibetuzumab (10 mg/kg; i.v.; once a week for 3, 5 or 6 weeks) exhibits antitumor effects on MET-amplified xenograft mouse tumor models.Animal Model:Athymic nude mice (U87MG tumor xenograft model).Dosage:10 mg/kg Administration: Intravenous injection, once a week for 5 weeks.Result:Demonstrated a significant inhibition of tumor growth.Animal Model:Athymic nude mice (MKN45 xenograft tumor model).Dosage:10 or 20 mg/kg Administration:Intravenous injection, single.Result:Reduced MET and pMET in the tumors by approximately 50% at both the 10 and 20 mg/kg doses by 72 hours post dose, and the reductions persisted to 14 days.Animal Model:Athymic nude mice (MET-amplified xenograft mouse tumor models).Dosage:10 mg/kg Administration:Intravenous injection, once a week for 3, 5 or 6 weeks. Result:Resulted in a marked reduction in tumor growth in the MKN45/SNU-5/EBC-1 gastric xenograft tumors.

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Angiogenesis

c-Met/HGFR

c-Met/HGFR

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1365287-97-3

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>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years