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Terevalefim

CAS No. 1070881-42-3

Terevalefim( ANG-3777 )

Catalog No. M28136 CAS No. 1070881-42-3

Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 116 In Stock
5MG 116 In Stock
10MG 211 In Stock
25MG 369 In Stock
50MG 526 In Stock
100MG 735 In Stock
200MG Get Quote In Stock
500MG 1507 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Terevalefim
  • Note
    Research use only, not for human use.
  • Brief Description
    Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor.
  • Description
    Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor.(In Vitro):Terevalefim (ANG-3777) (0-10 μM) significantly inhibited cancer cells proliferation in HUVECs.(In Vivo):Terevalefim (ANG-3777) decreases apoptosis, increases proliferation, and promotes organ repair and function in animal models.Terevalefim (ANG-3777, 40 mg/kg, IP) phosphorylates the c-Met receptor in rats.
  • In Vitro
    Cell Viability Assay Cell Line:Human Umbilical Vein Epithelial Cells (HUVECs).Concentration:0.44, 1.78, and 7.1 μM.Incubation Time:24 to 48 hours.Result:Dose-dependently inhibited cell proliferation.
  • In Vivo
    Animal Model:SD rats.Dosage:40 mg/kg.Administration:IP injection, once.Result:Selectively phosphorylated the c-Met receptor and not other growth factor receptors.
  • Synonyms
    ANG-3777
  • Pathway
    Angiogenesis
  • Target
    c-Met/HGFR
  • Recptor
    HMG-CoA Reductase (HMGCR)|Antifungal|sEH|Antioxidant
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1070881-42-3
  • Formula Weight
    176.24
  • Molecular Formula
    C9H8N2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (567.41 mM)
  • SMILES
    N/A
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lee GH, et al. Discovery of soluble epoxide hydrolase inhibitors from natural products. Food Chem Toxicol. 2014 Feb;64:225-30.
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