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Terevalefim
CAS No. 1070881-42-3
Terevalefim( ANG-3777 )
Catalog No. M28136 CAS No. 1070881-42-3
Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 116 | In Stock |
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| 5MG | 116 | In Stock |
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| 10MG | 211 | In Stock |
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| 25MG | 369 | In Stock |
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| 50MG | 526 | In Stock |
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| 100MG | 735 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 1507 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTerevalefim
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NoteResearch use only, not for human use.
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Brief DescriptionTerevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor.
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DescriptionTerevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor.(In Vitro):Terevalefim (ANG-3777) (0-10 μM) significantly inhibited cancer cells proliferation in HUVECs.(In Vivo):Terevalefim (ANG-3777) decreases apoptosis, increases proliferation, and promotes organ repair and function in animal models.Terevalefim (ANG-3777, 40 mg/kg, IP) phosphorylates the c-Met receptor in rats.
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In VitroCell Viability Assay Cell Line:Human Umbilical Vein Epithelial Cells (HUVECs).Concentration:0.44, 1.78, and 7.1 μM.Incubation Time:24 to 48 hours.Result:Dose-dependently inhibited cell proliferation.
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In VivoAnimal Model:SD rats.Dosage:40 mg/kg.Administration:IP injection, once.Result:Selectively phosphorylated the c-Met receptor and not other growth factor receptors.
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SynonymsANG-3777
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PathwayAngiogenesis
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Targetc-Met/HGFR
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RecptorHMG-CoA Reductase (HMGCR)|Antifungal|sEH|Antioxidant
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Research Area——
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Indication——
Chemical Information
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CAS Number1070881-42-3
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Formula Weight176.24
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Molecular FormulaC9H8N2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (567.41 mM)
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SMILESN/A
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lee GH, et al. Discovery of soluble epoxide hydrolase inhibitors from natural products. Food Chem Toxicol. 2014 Feb;64:225-30.
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