I-138( —— )

Catalog No. M36543 CAS No. 2098211-50-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

I-138
Note

Research use only, not for human use.
Brief Description

I-138 is an orally active and potent reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.
Description

I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells.
In Vitro

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In Vivo

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Synonyms

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Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

——
Indication

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CAS Number

2098211-50-6
Formula Weight

492.5
Molecular Formula

C26H23F3N6O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (203.05 mM; Ultrasonic )
SMILES

C(N1C=2C(NC1=O)=CN=C(N2)C3=C(C(C)C)C=CC=C3)C4=CC=C(C=C4)C5=NC(C(F)(F)F)=CN5C
Chemical Name

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1. Simoneau A, et al. Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer. Mol Cancer Ther. 2023 Feb 1;22(2):215-226.?

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