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Home - Products - Metabolic Enzyme/Protease - Phosphatase - BPDA2

BPDA2

CAS No. 2907659-86-1

BPDA2( —— )

Catalog No. M36541 CAS No. 2907659-86-1

BPDA2 is a highly selective and competitive SHP2 inhibitor, exhibiting IC50 values of 92.0 nM for SHP2, and 33.39 μM and 40.71 μM for SHP1 and SHP1B, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BPDA2
  • Note
    Research use only, not for human use.
  • Brief Description
    BPDA2 is a highly selective and competitive SHP2 inhibitor, exhibiting IC50 values of 92.0 nM for SHP2, and 33.39 μM and 40.71 μM for SHP1 and SHP1B, respectively.
  • Description
    BPDA2 is a highly selective and competitive active site SHP2 inhibitor with IC50s of 92.0 nM, 33.39 μM, 40.71 μM for SHP2, SHP1, SHP1B, respectively. DBDA2 downregulates mitogenic and cell survival signaling and RTK expression. BPDA2 suppresses SHP2 mediated signaling and breast cancer cell phenotypes.
  • In Vitro
    Western Blot Analysis Cell Line:JIMT-1, MDA-MB468 cell Concentration:0.2, 0.4, 0.8, 1.6, 3.2 μM Incubation Time:Result:Inhibited basal activation of Akt and ERK1/2 in a concentration dependent manner.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    Phosphatase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2907659-86-1
  • Formula Weight
    398.49
  • Molecular Formula
    C24H30O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)C=1C=C(C=CC1OCCCCCCCCC)C2=CC=C(C=C2)CC(=O)O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dhanaji M Lade, et al. Design and synthesis of improved active-site SHP2 inhibitors with anti-breast cancer cell effects. Eur J Med Chem. 2023 Feb 5;247:115017.?
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