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Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - BI?3231

BI?3231

CAS No. 2894848-07-6

BI?3231( —— )

Catalog No. M36527 CAS No. 2894848-07-6

BI 3231 is a selective and potent inhibitor of hydroxysteroid 17 -dehydrogenase 13 HSD17B13, inhibiting hHSD17B13 and mHSD17B13.BI-3231 can be used for the study of alcohol-associated liver injury, fibrosis and cirrhosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BI?3231
  • Note
    Research use only, not for human use.
  • Brief Description
    BI 3231 is a selective and potent inhibitor of hydroxysteroid 17 -dehydrogenase 13 HSD17B13, inhibiting hHSD17B13 and mHSD17B13.BI-3231 can be used for the study of alcohol-associated liver injury, fibrosis and cirrhosis.
  • Description
    BI 3231 is a potent and selective hydroxysteroid 17 -dehydrogenase 13 (HSD17B13) inhibitor, with IC50s of 1 and 13 nM for hHSD17B13 and mHSD17B13, respectively. BI 3231 has the potential for the research of nonalcoholic steatohepatitis (NASH) and other liver diseases.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    Dehydrogenase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2894848-07-6
  • Formula Weight
    380.37
  • Molecular Formula
    C16H14F2N4O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (328.63 mM; Ultrasonic (<60°C)
  • SMILES
    O=C1C(=CN(C(=O)N1CC)CC2=NN=C(S2)C=3C=CC(F)=C(O)C3F)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Thamm S, et, al. Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science. J Med Chem. 2023 Feb 2. ?
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