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Clozapine N-oxide dihydrochloride
CAS No. 2250025-93-3
Clozapine N-oxide dihydrochloride( —— )
Catalog No. M36444 CAS No. 2250025-93-3
Clozapine N-oxide dihydrochloride, a derivative of Clozapine and an agonist of human muscarinic design receptors (DREADDs), crosses the blood-brain barrier and activates DREADD receptors hM3Dq and hM4Di.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 44 | Get Quote |
|
| 10MG | 73 | Get Quote |
|
| 25MG | 117 | Get Quote |
|
| 50MG | 172 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameClozapine N-oxide dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionClozapine N-oxide dihydrochloride, a derivative of Clozapine and an agonist of human muscarinic design receptors (DREADDs), crosses the blood-brain barrier and activates DREADD receptors hM3Dq and hM4Di.
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DescriptionClozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetAChE
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RecptorAChE
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Research Area——
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Indication——
Chemical Information
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CAS Number2250025-93-3
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Formula Weight452.2
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Molecular FormulaC18H22Cl4N4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 240 mg/mL (577.28 mM; Ultrasonic ) H2O : 100 mg/mL (240.53 mM; Ultrasonic)
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SMILESC[N+]1([O-])CCN(CC1)C2=NC3=CC(Cl)=CC=C3NC4=C2C=CC=C4.Cl.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wess J, et al. Novel designer receptors to probe GPCR signaling and physiology. Trends Pharmacol Sci. 2013 Jul;34(7):385-92.?
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