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JB062

CAS No. 2417988-00-0

JB062( —— )

Catalog No. M36106 CAS No. 2417988-00-0

JB062 is a chemical compound acting as a nonmuscle myosin inhibitor, exhibiting IC50 values of 1.6, 5.4, and >100 μM against skeletal muscle myosin, cardiac muscle myosin, and smooth muscle myosin II, respectively.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	458	In Stock
5MG	466	In Stock
10MG	679	In Stock
25MG	1036	In Stock
50MG	1376	In Stock
100MG	1841	In Stock
200MG	Get Quote	In Stock
500MG	3692	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

JB062
Note

Research use only, not for human use.
Brief Description

JB062 is a chemical compound acting as a nonmuscle myosin inhibitor, exhibiting IC50 values of 1.6, 5.4, and >100 μM against skeletal muscle myosin, cardiac muscle myosin, and smooth muscle myosin II, respectively.
Description

JB062 is a nonmuscle myosin inhibitor with IC50 values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Myosin
Recptor

Myosin
Research Area

——
Indication

——

Chemical Information

CAS Number

2417988-00-0
Formula Weight

323.34
Molecular Formula

C19H17NO4
Purity

>98% (HPLC)
Solubility

——
SMILES

OC=1C=2C(OC(=O)C1C(=NCC3=CC=C(OC)C=C3)C)=CC=CC2
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Smith JD, et, al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2022 Dec 12;247:115008.?

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