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Danicamtiv
CAS No. 1970972-74-7
Danicamtiv( MYK-491 | SAR 440181 )
Catalog No. M23890 CAS No. 1970972-74-7
Danicamtiv is an inotropic agent and it also is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 260 | In Stock |
|
| 10MG | 430 | In Stock |
|
| 25MG | 710 | In Stock |
|
| 50MG | 972 | In Stock |
|
| 100MG | 1332 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameDanicamtiv
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NoteResearch use only, not for human use.
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Brief DescriptionDanicamtiv is an inotropic agent and it also is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.
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DescriptionDanicamtiv is an inotropic agent and it also is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.
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In Vitro——
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In VivoDanicamtiv selectively enhances cardiac actomyosin activity, the molecular force‐generating unit of the sarcomere, prolonging contraction while preserving actin–myosin detachment, allowing relaxation, and without impacting Ca2+ homeostasis.
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SynonymsMYK-491 | SAR 440181
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetMyosin
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Recptorhuman cardiac
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Research Area——
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Indication——
Chemical Information
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CAS Number1970972-74-7
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Formula Weight435.42
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Molecular FormulaC16H20F3N5O4S
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Purity>98% (HPLC)
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SolubilityDMSO:50mg/ml (114.83mM; Need ultrasonic)
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SMILESC[C@@](C(CC1)CCN1C(Nc1nocc1)=O)(F)S(c1cn(C)nc1C(F)F)(=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sarah Fernandes, et al. Abstract 15707: MYK-491, a Novel Small-Molecule Cardiac Myosin Activator Increases Cardiac Systolic Function and Preserves Mechanical Efficiency: Pre-Clinical in vivo and in vitro Evidence. Circulation. 2019;140:A15707
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