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Home - Products - Cell Cycle/DNA Damage - GPR - BTB09089

BTB09089

CAS No. 245728-44-3

BTB09089( —— )

Catalog No. M36055 CAS No. 245728-44-3

BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production in T cells and macrophages.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    BTB09089
  • Note
    Research use only, not for human use.
  • Brief Description
    BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8/GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production in T cells and macrophages.
  • Description
    BTB09089 is a T cell death-associated gene 8 (TDAG8/GPR65) specific agonist. BTB09089 increases TDAG8 expression and regulates the cytokine production of T cells and macrophages.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Adult male SD rats (270-280 g), middle cerebral artery occlusion (MCAO) model Dosage:5, 10 and 20 μM, 8 μL Administration:Intracerebroventricular injection, six hours prior to MCAO Result:Up-regulated TDAG8 and Bcl-2 expression and down-regulated cleaved caspase-3 expression, while the infarction volume was reduced, and neurological deficits were ameliorated 24 and 72 h after MCAO.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    GPR | DNA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    245728-44-3
  • Formula Weight
    387.31
  • Molecular Formula
    C14H12Cl2N4OS2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (258.19 mM; Ultrasonic (<80°C)
  • SMILES
    CN1C2=C(SC(SCC3=C(Cl)C=C(Cl)C=C3)=N1)C(=O)N(C)N=C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Onozawa Y, et al. Activation of T cell death-associated gene 8 regulates the cytokine production of T cells and macrophages in vitro. Eur J Pharmacol. 2012 May 15;683(1-3):325-31.?
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