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Home - Products - Cell Cycle/DNA Damage - GPR - GSK256073

GSK256073

CAS No. 862892-90-8

GSK256073( —— )

Catalog No. M24859 CAS No. 862892-90-8

GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 169 In Stock
2MG 93 In Stock
5MG 155 In Stock
10MG 250 In Stock
25MG 440 In Stock
50MG 634 In Stock
100MG 901 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    GSK256073
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist.
  • Description
    GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist (pEC50: 7.5). GSK256073 acutely improves glucose homeostasis via inhibition of lipolysis.
  • In Vitro
    ——
  • In Vivo
    Animal Model:SD ratDosage:1, 30 and 100 mg/kg Administration:Oral adminstration Result:Inhibited NEFA expression as a dose-dependent manner. Animal Model:Guinea pigs Dosage:10 mg/kg Administration: Intravenous?injection Result:Had the antilipolytic and flushing effects as a HCA2 agonist.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    GPR109A|HCA2 (hydroxy-carboxylic acid receptor 2)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    862892-90-8
  • Formula Weight
    256.69
  • Molecular Formula
    C10H13ClN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:16.67 mg/mL?(64.94 mM;?Need ultrasonic)
  • SMILES
    CCCCCN1C2=C(C(=O)NC1=O)NC(=N2)Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dobbins RL, et al. GSK256073, a selective agonist of G-protein coupled receptor 109A (GPR109A) reduces serum glucose in subjects with type 2 diabetes mellitus.Diabetes Obes Metab.?2013 Nov;15(11):1013-21.
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