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Home - Products - GPCR/G Protein - Dopamine Receptor - UCM-1306

UCM-1306

CAS No. 2258608-78-3

UCM-1306( —— )

Catalog No. M35941 CAS No. 2258608-78-3

UCM-1306 is a potent and orally active allosteric modulator (PAM) of the human dopamine D1 receptor. It increases the maximal effect of endogenous dopamine (DA) in both human and mouse D1 receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    UCM-1306
  • Note
    Research use only, not for human use.
  • Brief Description
    UCM-1306 is a potent and orally active allosteric modulator (PAM) of the human dopamine D1 receptor. It increases the maximal effect of endogenous dopamine (DA) in both human and mouse D1 receptors.
  • Description
    UCM-1306 is a potent and orally active human dopamine D1 receptor allosteric modulator (PAM). UCM-1306 increases the endogenous dopamine (DA) maximal effect both in human and mouse D1 receptors. UCM-1306 is not only for improving motor symptoms but also for addressing the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD).
  • In Vitro
    ——
  • In Vivo
    Animal Model:Adult C57BL/6J mice with cocaine-induced hyperactivity model Dosage:1 mg/kg; cocaine (20 mg/kg, sc) Administration:Intraperitoneal injection Result:Increased cocaine-induced hyperlocomotion, suggesting an in vivo potentiation of DA action at the D1R.Animal Model:Adult C57BL/6J mice Dosage:1 mg/kg Administration:Intraperitoneal injection Result:Increased memory trace in C57BL/6J mice.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    Dopamine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2258608-78-3
  • Formula Weight
    279.33
  • Molecular Formula
    C14H14FNO2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (179.00 mM; Ultrasonic )
  • SMILES
    CS(=N)(=O)c1ccc(cc1)-c1ccccc1OCF
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. García-Cárceles J, et, al. 2-(Fluoromethoxy)-4'-(S-methanesulfonimidoyl)-1,1'-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson's Disease. J Med Chem. 2022 Sep 22;65(18):12256-12272.?
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