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CyPPA

CAS No. 73029-73-9

CyPPA( —— )

Catalog No. M24739 CAS No. 73029-73-9

CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 33 In Stock
5MG 53 In Stock
10MG 76 In Stock
25MG 160 In Stock
50MG 266 In Stock
100MG 441 In Stock
500MG 972 In Stock
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Biological Information

  • Product Name
    CyPPA
  • Note
    Research use only, not for human use.
  • Brief Description
    CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.
  • Description
    CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.
  • In Vitro
    CyPPA induces a concentration-dependent increase in the apparent Ca2+-sensitivity of channel activation, changing the EC50 (Ca2+) from 429 nM to 59 nM.
  • In Vivo
    CyPPA, a positive modulator of small-conductance Ca2+-activated K+ channels, inhibits phasic uterine contractions and delays preterm birth in mice.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    Dopamine| SK3| SK2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    73029-73-9
  • Formula Weight
    285.39
  • Molecular Formula
    C16H23N5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 99 mg/mL (346.89 mM; Need ultrasonic)
  • SMILES
    Cc1cc(C)nn1-c1nc(NC2CCCCC2)cc(C)n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Herrik KF, et al.CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Front Pharmacol. 2012 Feb 13;3:11.
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