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CyPPA
CAS No. 73029-73-9
CyPPA( —— )
Catalog No. M24739 CAS No. 73029-73-9
CyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 61 | In Stock |
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| 2MG | 35 | In Stock |
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| 5MG | 56 | In Stock |
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| 10MG | 80 | In Stock |
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| 25MG | 169 | In Stock |
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| 50MG | 275 | In Stock |
|
| 100MG | 456 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1004 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCyPPA
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NoteResearch use only, not for human use.
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Brief DescriptionCyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.
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DescriptionCyPPA, a subtype-selective positive modulator of SK channels, decreased spontaneous firing rate, increased the duration of the apamin-sensitive afterhyperpolarization.
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In VitroCyPPA induces a concentration-dependent increase in the apparent Ca2+-sensitivity of channel activation, changing the EC50 (Ca2+) from 429 nM to 59 nM.
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In VivoCyPPA, a positive modulator of small-conductance Ca2+-activated K+ channels, inhibits phasic uterine contractions and delays preterm birth in mice.
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Synonyms——
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorDopamine| SK3| SK2
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Research Area——
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Indication——
Chemical Information
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CAS Number73029-73-9
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Formula Weight285.39
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Molecular FormulaC16H23N5
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Purity>98% (HPLC)
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SolubilityDMSO : 99 mg/mL (346.89 mM; Need ultrasonic)
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SMILESCc1cc(C)nn1-c1nc(NC2CCCCC2)cc(C)n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Herrik KF, et al.CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Front Pharmacol. 2012 Feb 13;3:11.
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