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Anti-inflammatory agent 36

CAS No. 2293951-01-4

Anti-inflammatory agent 36( —— )

Catalog No. M35803 CAS No. 2293951-01-4

Anti-inflammatory agent 36 is an anti-inflammatory agent that exhibited dose-dependent inhibition of LPS-induced release of TNF-a and IL-6 in active RAW 264.7 mouse macrophages (IC50 = 3.69 μM and 3.68 μM, respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 51 In Stock
5MG 41 In Stock
10MG 69 In Stock
25MG 136 In Stock
50MG 216 In Stock
100MG 322 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Anti-inflammatory agent 36
  • Note
    Research use only, not for human use.
  • Brief Description
    Anti-inflammatory agent 36 is an anti-inflammatory agent that exhibited dose-dependent inhibition of LPS-induced release of TNF-a and IL-6 in active RAW 264.7 mouse macrophages (IC50 = 3.69 μM and 3.68 μM, respectively).
  • Description
    Anti-inflammatory agent 36 is an anti-inflammatory agent. Anti-inflammatory agent 36 inhibits LPS-induced macrophage activation.
  • In Vitro
    Western Blot Analysis Cell Line:RAW 264.7 mouse macrophages Concentration:10 μM Incubation Time:0.5 h Result:Markedly inhibited P-P38 and P-ERK, indicating the suppression of MAPK signaling.
  • In Vivo
    Animal Model:Acute lung injury mouse model Dosage:10 mg/kg Administration:i.p.Result:Reduced wet/dry weight ratio of the mice lungs.Reduced biomarkers of lymphocytes and macrophages.Suppresses TNF-α, IL-6, IL-1β, 7 VACM-1 and ICAM-1 level.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Immunology/Inflammation related
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2293951-01-4
  • Formula Weight
    453.48
  • Molecular Formula
    C25H27NO7
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (55.13 mM; Ultrasonic (<60°C)
  • SMILES
    COc1cc(\C=C\C(=O)N2CCC\C(=C/c3cc(OC)c(OC)c(OC)c3)C2=O)ccc1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Qian J, et al. Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI). Eur J Med Chem. 2019 Apr 1;167:414-425. ?
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