Sunvozertinib( —— )

Catalog No. M35766 CAS No. 2370013-12-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Sunvozertinib
Note

Research use only, not for human use.
Brief Description

Sunvozertinib (DZD9008) is a potent ErbBs and BTK inhibitor, with inhibitory effects on EGFR, Her2, and mutant epidermal growth factor.
Description

Sunvozertinib (DZD9008) is a potent ErbBs (EGFR, Her2, especially mutant forms) and BTK inhibitor. Sunvozertinib shows IC50s of 20.4, 20.4, 1.1, 7.5, and 80.4 nM for EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, and Her2 Exon20 YVMA, and EGFR WT A431, respectively (patent WO2019149164A1, example 52).
In Vitro

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In Vivo

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Synonyms

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Pathway

Angiogenesis
Target

EGFR
Recptor

EGFR | BTK
Research Area

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Indication

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CAS Number

2370013-12-8
Formula Weight

584.08
Molecular Formula

C29H35ClFN7O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (85.60 mM; Ultrasonic (<80°C)
SMILES

COc1cc(N2CC[C@H](C2)N(C)C)c(NC(=O)C=C)cc1Nc1nccc(Nc2cc(Cl)c(F)cc2C(C)(C)O)n1
Chemical Name

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1. Zhengtao LI, et al. Erbb/btk inhibitors. WO2019149164A1.

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