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CFTR corrector 8
CAS No. 1918142-35-4
CFTR corrector 8( —— )
Catalog No. M35744 CAS No. 1918142-35-4
CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 92 | In Stock |
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| 5MG | 71 | In Stock |
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| 10MG | 111 | In Stock |
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| 25MG | 224 | In Stock |
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| 50MG | 345 | In Stock |
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| 100MG | 566 | In Stock |
|
| 200MG | 762 | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCFTR corrector 8
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NoteResearch use only, not for human use.
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Brief DescriptionCFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR).
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DescriptionCFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis.
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In VitroCFTR corrector 8 (compound 12) shows EC50s of 1 μM (CSE-HRP assay) and 3 μM (HBE-TECC assay) .CFTR corrector 8 exhibits hepatocyte clearance rate of 1250/775 L/hr/kg (human/rat).
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetCFTR
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RecptorCFTR
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Research Area——
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Indication——
Chemical Information
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CAS Number1918142-35-4
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Formula Weight539.52
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Molecular FormulaC29H27F2NO7
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 110 mg/mL (203.88 mM; Ultrasonic )
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SMILESCOc1ccc2[C@H](C[C@H](Oc2c1)c1ccc(OC)c(OC)c1)NC(=O)C1(CC1)c1ccc2OC(F)(F)Oc2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wang X, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. J Med Chem. 2018 Feb 22;61(4):1436-1449. ?
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