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CFTR corrector 8

CAS No. 1918142-35-4

CFTR corrector 8( —— )

Catalog No. M35744 CAS No. 1918142-35-4

CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    CFTR corrector 8
  • Note
    Research use only, not for human use.
  • Brief Description
    CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR).
  • Description
    CFTR corrector 8 is a potent CFTR modulator. CFTR can be used in the research of cystic fibrosis.
  • In Vitro
    CFTR corrector 8 (compound 12) shows EC50s of 1 μM (CSE-HRP assay) and 3 μM (HBE-TECC assay) .CFTR corrector 8 exhibits hepatocyte clearance rate of 1250/775 L/hr/kg (human/rat).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    CFTR
  • Recptor
    CFTR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1918142-35-4
  • Formula Weight
    539.52
  • Molecular Formula
    C29H27F2NO7
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 110 mg/mL (203.88 mM; Ultrasonic )
  • SMILES
    COc1ccc2[C@H](C[C@H](Oc2c1)c1ccc(OC)c(OC)c1)NC(=O)C1(CC1)c1ccc2OC(F)(F)Oc2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wang X, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. J Med Chem. 2018 Feb 22;61(4):1436-1449. ?
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