NF-κB/MAPK-IN-1( —— )

Catalog No. M35698 CAS No. 2413940-56-2

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Datasheet

HNMR

HPLC

MSDS

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Product Name

NF-κB/MAPK-IN-1
Note

Research use only, not for human use.
Brief Description

NF-κB/MAPK-IN-1 is a potent dual inhibitor of the NF-κB and MAPK pathways with potential anti-inflammatory activity, inhibition of NO production, and inhibition of LPS-induced activation of iNOS, COX-2, ERΚ and P38.
Description

NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC50 of 6.96 μM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Apoptosis
Target

NF-κB
Recptor

NF-κB | MAPK
Research Area

——
Indication

——

CAS Number

2413940-56-2
Formula Weight

477.51
Molecular Formula

C27H27NO7
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (209.42 mM; Ultrasonic )
SMILES

O(C1=C(C(C)=O)C=CC(OC)=C1)C2=CC=C(NC(/C=C/C3=CC(OC)=C(OC)C(OC)=C3)=O)C=C2
Chemical Name

——

1. Hu YS, et al. Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivo. Bioorg Chem. 2020 May;98:103735. ?

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