Ergolide

CAS No. 54999-07-4

Ergolide( —— )

Catalog No. M24538 CAS No. 54999-07-4

Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 169 In Stock
5MG 142 In Stock
10MG 242 In Stock
25MG 394 In Stock
50MG 537 In Stock
100MG 720 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Ergolide
  • Note
    Research use only, not for human use.
  • Brief Description
    Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB.
  • Description
    Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB. Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    NF-κB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    54999-07-4
  • Formula Weight
    306.35
  • Molecular Formula
    C17H22O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:50 mg/mL (163.21 mM; Need ultrasonic)
  • SMILES
    C[C@H](C[C@@H]([C@H]([C@@H]1OC(C)=O)C2=C)OC2=O)[C@H](CC2)[C@@]1(C)C2=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Whan Han J, et al. Ergolide, sesquiterpene lactone from Inula britannica, inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-kappaB. Br J Pharmacol. 2001 Jun;133(4):503-12.
molnova catalog
related products
  • methyl chlorogenate

    Methyl chlorogenate is isolated from Eriobotrya japonica which is the inhibitor of NFkappaB.

  • Ethyl caffeate

    Ethyl caffeate is a potent chemopreventive compound against skin carcinogenesis caused by solar UV exposure.

  • Scandoside

    Scandoside, a cyclic enolide that can be isolated from Haemophilus difficile, exhibits anti-inflammatory activity, inhibits the expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), TNF-α, and IL-6 messenger RNA (mRNA), and inhibits the nuclear transcription factor, kappa-B alpaha (IκB-α), p38, extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) inhibitor phosphorylation.