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CHD1Li 6.11

CAS No. 2716890-91-2

CHD1Li 6.11( —— )

Catalog No. M35689 CAS No. 2716890-91-2

CHD1Li 6.11 is a potent inhibitor of oncogenic CHD1L, acting on the cat-CHD1L recombinant protein (IC50: 3.3 μM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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5MG	217	Get Quote
10MG	353	Get Quote
25MG	579	Get Quote
50MG	824	Get Quote
100MG	1098	Get Quote
500MG	2205	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

CHD1Li 6.11
Note

Research use only, not for human use.
Brief Description

CHD1Li 6.11 is a potent inhibitor of oncogenic CHD1L, acting on the cat-CHD1L recombinant protein (IC50: 3.3 μM).
Description

CHD1Li 6.11 is a potent oncogenic CHD1L inhibitor (IC50=3.3 μM for cat-CHD1L recombinant protein).CHD1Li 6.11 is an orally bioavailable antitumor agent, significantly reducing the tumor volume of CRC xenografts generated from isolated quasi mesenchymal cells (M-phenotype), which possess enhanced tumorigenic properties.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

2716890-91-2
Formula Weight

472.4
Molecular Formula

C21H22BrN5OS
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (211.69 mM; Ultrasonic )
SMILES

Cc1cc(Nc2ccc(NC(=O)Cc3cc(Br)cs3)cc2)nc(n1)N1CCCC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Prigaro BJ, et al. Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L. J Med Chem. 2022;65(5):3943-3961. ?

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