Ademetionine disulfate tosylate

Research use only, not for human use.

Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions.

Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.

Apoptosis Analysis Cell Line:Cal-33 and JHU-SCC-011 cells Concentration:300 μM Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011)Result:Showed an approximately 10% and 3% of apoptotic cells respectively.Cell Cycle Analysis Cell Line:Cal-33 and JHU-SCC-011 cells Concentration:300 μM Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011) Result:Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.

Animal Model:Valproic acid treated young miceDosage:30?mg/kg Administration:p.o., for 3 days Result:Alleviated most ASD like neurobehavioral symptoms.Normalized the redox potential in the prefrontal cortex.

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Others

Other Targets

APE1(Ref-1)

Others-Field

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97540-22-2

766.8

C22H34N6O16S4

>98% (HPLC)

DMSO : ≥ 50 mg/mL 65.21 mM H2O : 33.33 mg/mL 43.47 mM

OS(O)(=O)=O.OS(O)(=O)=O.CC1=CC=C(C=C1)S(O)(=O)=O.C[S+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12

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(-20℃)

With Ice Pack

≥ 2 years