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D-3263 hydrochloride
CAS No. 1008763-54-9
D-3263 hydrochloride( D3263 HCl salt | EC D-3263 HCl )
Catalog No. M26136 CAS No. 1008763-54-9
D-3263 hydrochloride is enteric-coated, orally bioavailable (transient receptor potential melatonin member 8) TRPM8 agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 55 | In Stock |
|
| 5MG | 64 | In Stock |
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| 10MG | 101 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameD-3263 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionD-3263 hydrochloride is enteric-coated, orally bioavailable (transient receptor potential melatonin member 8) TRPM8 agonist.
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DescriptionD-3263 hydrochloride is enteric-coated, orally bioavailable (transient receptor potential melatonin member 8) TRPM8 agonist.(In Vitro):D-3263 hydrochloride binds and activates TRPM8, which may lead to increased entry of calcium and sodium; destruction of calcium and sodium homeostasis; induction of cell death in tumor cells expressing TRPM8. D-3263 hydrochloride may reduce the level of dihydrotestosterone (DHT), which may contribute to its inhibitory effect on prostate cancer and BPH.
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In VitroD-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. D-3263 hydrochloride may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH.?
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In Vivo——
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SynonymsD3263 HCl salt | EC D-3263 HCl
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PathwayOthers
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TargetOther Targets
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RecptorGnRHR
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Research Area——
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Indication——
Chemical Information
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CAS Number1008763-54-9
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Formula Weight409.96
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Molecular FormulaC21H32ClN3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 140 mg/mL (341.51 mM)
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SMILESCl.COc1ccc2n(C(=O)[C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(=O)n(CCN)c2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ezzati M, Carr BR (2015).?"Elagolix, a novel, orally bioavailable GnRH antagonist under investigation for the treatment of endometriosis-related pain".?Womens Health (Lond).?11?(1): 19–28.
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