Cart
sales@molnova.com
Home - Products - Apoptosis - Ferroptosis - BCP-T.A

BCP-T.A

CAS No. 2786829-70-5

BCP-T.A( —— )

Catalog No. M35673 CAS No. 2786829-70-5

BCP-T.A is an ferroptosis inducer that acts by binding to GPX4.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 119 Get Quote
5MG 302 Get Quote
10MG 561 Get Quote
25MG 868 Get Quote
50MG 1178 Get Quote
100MG 1557 Get Quote
200MG 2097 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    BCP-T.A
  • Note
    Research use only, not for human use.
  • Brief Description
    BCP-T.A is an ferroptosis inducer that acts by binding to GPX4.
  • Description
    BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4. BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • In Vitro
    BCP-T.A induces ferroptosis in various cell lines (NCI-H522, T-1080, MDA-MB-468, MDA-MB-231, HeLa, HCT-116, U2OS, WI-38, and MEFS) with IC50 values of 10 nM-367 nM.BCP-T.A (0.5 μM, 3 h) binds to GPX4 and increases lipid peroxides, indicated by cellular thermal shift assay (CETSA).
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Ferroptosis
  • Recptor
    Ferroptosis | GPX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2786829-70-5
  • Formula Weight
    456.39
  • Molecular Formula
    C23H19Cl2N3OS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C=1N=C(C#C)SC1)N2CCN(CC2)C(C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Endri Karaj, et al. Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues. J Med Chem. 2022 Aug 19. ?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Erastin

    Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS.

  • RSL-3

    An oncogenic RAS-selective lethal compound that actvates iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

  • UAMC-3203

    UAMC-3203 is a novel potent, drug-like ferroptosis inhibitor with IC50 of 12 nM.

Sign In Join Free