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FINO2

CAS No. 869298-31-7

FINO2( —— )

Catalog No. M35322 CAS No. 869298-31-7

FINO2 is a potent ferroptosis-inducing compound that inhibits GPX4 activity. It functions as a stable oxidant, effectively oxidizing ferrous iron and demonstrating stability across varying pH levels.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    FINO2
  • Note
    Research use only, not for human use.
  • Brief Description
    FINO2 is a potent ferroptosis-inducing compound that inhibits GPX4 activity. It functions as a stable oxidant, effectively oxidizing ferrous iron and demonstrating stability across varying pH levels.
  • Description
    FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation.
  • In Vitro
    FINO2 (10 μM; 24 h) induce ferroptosis and shows iron dependence of lipid peroxidation in HT-1080 cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Ferroptosis
  • Recptor
    Ferroptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    869298-31-7
  • Formula Weight
    256.38
  • Molecular Formula
    C15H28O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (195.02 mM; Ultrasonic )
  • SMILES
    CC(C)(C)[C@H]1CC[C@]2(CC(C)(CCO)OO2)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gaschler MM, et al. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018 May;14(5):507-515. ?
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